Welcome!

 

I am a research scientist for the CNRS (Centre National de la Recherche Scientifique) working at the Institute for Structural Biology (IBS) in Grenoble, France.

 

My research interest in the PIXEL team is centered on the engineering and characterization of fluorescent proteins, using a set of techniques: molecular biology, biochemistry, kinetic X-ray crystallography, spectroscopy and single-molecule localization microscopy.

 

On this website, you will find all relevant information about my work-related activities: from my CV, including the list of my publications and my Ph.D. thesis to details about my past and current research projectsA list of my deposited 3D atomic structures is available as well as a selection of videos representative of my research career. You can also consult my presentations  (conferences & posters), public communication actions and teaching experience. Awards I received and coverage of some results by media are detailed on dedicated pages.

 

Would you have some questions or requests, please contact me or leave a comment or/and connect to any professional network by clicking on the icons at the bottom of each page.

July 9, 2019

Nat Methods (2019) "Mechanistic investigation of mEos4b reveals a strategy to reduce track interruptions in sptPALM"

Green-to-red photoconvertible fluorescent proteins repeatedly enter dark states, causing interrupted tracks in single-particle-tracking localization microscopy (sptPALM). We identified a long-lived dark state in photoconverted mEos4b that results from isomerization of the chromophore and efficiently absorbs cyan light. Addition of weak 488-nm light swiftly reverts this dark state to the fluorescent state. This strategy largely eliminates slow blinking and enables the recording of longer tracks in sptPALM with minimum effort.

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© 2014-2019 Virgile Adam. All rights reserved

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